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Sniffing Out Human Sex Pheromones

by Rick Weiss, Washington Post Staff Writer

Scientists Find Proof of 'Chemistry' Between People

Scientists have found long-sought proof that people release potent chemical signals that can have profound effects on other people.

The research settles a 40-year debate about whether humans produce and can respond to “pheromones,” molecules that are usually airborne and odorless and which, in other species, influence such physiological processes and behaviors as mate choice, the recognition of one’s own family members, and the ability to “smell” the difference between friend and foe.

Specifically, the new research shows that women’s underarm odors can alter the timing of other women’s reproductive cycles. It explains why women who live together often develop synchronous menstrual periods, and could spur development of “natural” fertility drugs or contraceptives.

The finding may also lead to the discovery of compounds in sweat that could be incorporated into fragrances to alter body chemistry or mood.

“This is definitely going to make people sit up and take notice,” said Charles J. Wysocki of the Monell Chemical Senses Center in Philadelphia. Previous studies by scientists at Monell and elsewhere showed similar results but later were recognized as flawed. The new work, Wysocki said, seems to answer the question for good.

“The evidence has now become quite strong that humans produce and detect pheromones,” agreed Edward W. Johnson of Idaho State University in Pocatello.

The discovery was especially gratifying to Martha K. McClintock, the University of Chicago researcher who, with colleague Kathleen Stern, describes the work in today’s issue of the journal Nature. As an undergraduate almost 30 years ago, McClintock observed that many women in her dormitory menstruated in synchrony.

For decades McClintock immersed herself in the task of identifying the timing mechanism. She and others suspected pheromones, but proof was hard to come by.

Pheromones have been documented in many species, ranging from insects to elephants, as sex attractants, kinship identifiers or alarm signals. In many species they are detected by a specialized organ inside the nose or mouth called the vomeronasal organ, or VNO.

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There was ample evidence that human pheromones exist; babies show a clear preference for pieces of clothing that have been worn by their own mothers, for example, and research suggests that men and women choose their mates in part by sniffing out partners with compatible immune systems. Several years ago, researchers in Utah even said they had identified the first human pheromones — and turned their discovery into a line of perfumes that today boasts revenue of $40 million a year.

But the Utah work has been criticized by many experts. And the Monell work, on menstrual cycles, did not take into consideration the fact that many out-of-phase cycles will naturally converge over time.

Moreover, scientists have remained uncertain whether the human VNO, a pair of tiny pits in the nose, is a functional organ or an evolutionary vestige.

To find out if human pheromones exist and can affect menstrual timing, McClintock and Stern asked nine women to wear gauze pads under their armpits all day. (Sweat is a common source of pheromones in mammals.) The pads, changed daily, were cut into pieces and frozen, and a daily tally was kept of each woman’s menstrual phase.

Then, every day for four months, the researchers rubbed thawed gauze pads above the upper lips of 20 volunteer women who had agreed to have any of 30 different “natural essences” rubbed under their noses. “Sweat” was among the 30. “We buried it in the list,” McClintock said.

For two months, 10 women sniffed sweat from women in the early phase of their menstrual cycle, while the other 10 sniffed sweat from women in a later phase of their cycle. Then the groups switched and spent two months getting the opposite scent.

The women smelled nothing, but the results were striking: Those exposed to “early phase” sweat saw their own cycles shortened by an average of 1.7 days per month, and as much as 14 days a month. Those who sniffed “later phase” sweat saw their cycles lengthened by an average of 1.4 days a month, and up to 12 days a month.

Computer models indicated there must be two substances in the sweat — one that lengthens cycles and one that shortens them — and that together they can quickly lead to groups of women having synchronous periods.

“This carefully controlled study clearly shows, for the first time, that the potential for chemical communication involving sexual function has been preserved in humans during evolution,” wrote Aron Weller, of Israel’s Bar-Ilan University, in a commentary in Nature.

McClintock emphasized the word “potential,” since the experiment does not prove these signals work under normal conditions, such as across a room.

“We put it on the upper lip,” McClintock said, “so really we know absolutely nothing about where it is acting, whether it’s through the skin, the mucus membranes in the nose or the VNO.” Nonetheless, practical uses could follow.

“The whole point would be to see what the compounds are and how do they act and what is their natural route and see whether we could develop a highly efficient ovarian modulator,” McClintock said. A drug that constantly delays ovulation could serve as a contraceptive, while one that prompts ovulation might cure some kinds of infertility.

Linda Buck of Harvard University, who studies the molecular genetics of smell, said she has been unable to find functioning VNO genes in people. But some animals detect pheromones with their normal nasal cells, she said, and humans may too.

If pheromones have a big effect on human physiology, people may want to rethink their heavy use of soaps and perfumes: It may be, Buck speculated, that the constant washing away or covering up of these sweaty social signals account for some of the loneliness or depression in modern society.

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Tuesday, May 25th, 2010 Discount Pheromones, odorless pheromones, Pheromone News, Pheromone Testimonials, pheromones, Science of Seduction, Sexual Attraction is Chemistry, Top 5 Pheromones 1 Comment

Another Nite in Pheromone Paradise…

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Looking for Love?

Hey guys… Jessie here.  The female persuasion.  I will answer any of your questions on love, dating or sex.  I have guys hitting on me all the time and very few can get and/or keep my attention.  However, I can give you some tips on how to attract the girl of your dreams.  Everyone has different needs and wants but attracting women is the same.  That being said… attracting for a one night stand and attracting for a relationship are two different beasts.

So, let’s take a poll so I can see what the majority of people are looking for.  The stuff works great for women too!

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Do Pheromones Work? Look at what Real People are saying

Read these testimonials, and decide for yourself if we’ve accomplished our goal! These are ACTUAL CUSTOMER TESTIMONIALS – not fiction written by a programmer! These folks were HAPPY to let us use their names !

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Dial Magnetic | Pheromones have Finally Penitrated the Mainstream!

U.S. soap maker Dial (Proctor & Gamble) have entered the pheromone market with a body wash targeted at men called Dial Magnetic. Sure enough if you read the ingredients in does contain androstenone. That’s a good thing. However, P & G made one fatal error with this highly promoted product… Read More Below…


Dial is just now discovering what “The Pheromone King” has known for over a decade. Androstenone Pheromones work to attract women.
Here’s the rub. What do you do with soap? Wash. What does washing do? It removes stuff. So let’s get this strait. You put it on, then wash it off. Well, basic logic will tell you, that’s not how it’s done.

The silver lining: Mainstream corporations (Proctor & Gamble being one of the largest in the world) are openly acknowledging that androstenone pheromones work to attract. The bad news for Dial is, they chose the absolute worst delivery system possible. Soap.

Dolars and cents: The core ingredient of any legitimate pheromone product is androstenone. Pure androstenone is very expensive. The art of producing an effective pheromone product lies in the perfect combination of complementary compounds in a super effective delivery system. When this achieved, the maximum amount of androstenone ends up where it belongs. On the Guy (not running down his shower drain). With that said, the soap may only contain trace amounts of androstenone. It’s simply too expensive to pour down the drain, however mentioning pheromones on the label is a great way to get people to buy a product. You gotta give them credit in the marketing department. Unfortunately marketing won’t get you a hot girlfriend:(

The real deal: Phermax is a ultra concentrated androstenone pheromone based formula, perfected, that uses a atomizer spray delivery system, so every molecule of androstenone ends up right where it belongs. On you. The True Human Sex Attractor.

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“I got Phermax to heat things with the wife.  Next thing I know I’m selling more cars, go figure.  Now things are good at home and at work;)” Dave B. North Hollywood ,CA

“I’ve always been a kinda uptight guy.  One spray of Phermax and I get a very calm and confident feeling.  Girls seem to pick up on it cuz I’m getting dates now without really trying.  Chris J. Austin, TX

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You can’t see them, feel them, or smell them, but they may have a huge influence on whom you find attractive. No, they aren’t Cupid’s invisible henchmen, although their effect might be just as magical. They’re pheromones, chemical messengers emitted by one creature to evoke a response in another of the same species.

Pheromones are blends of chemicals, including acetates and aldehydes, and different combinations are thought to send different signals. For decades, scientists have studied them in bugs. A female moth, for example, emits pheromones from a gland on her abdomen. A male moth is aroused by the signal, flies up to 30 miles to find the female, and mates with her. Since 1959, we’ve synthesized insect pheromones to control pest populations – for example, to confuse males so they can’t find the females.

Human pheromones are the subject of much debate. Their role in human attraction is controversial, in part because the nasal ducts that animals use to sense pheromones appear to be inactive in people (some researchers claim that’s not true – we just haven’t found the nerve that makes it possible).

Most researchers agree human pheromones exist. This agreement is due in part to a 1971 study that showed that the menstrual cycles of women who live or work together tend to synchronize over time. Researchers believe that this may be the result of picking up on each other’s pheromones.

Other studies have compared men’s and women’s responses to hormone-like chemicals, such as androstadienone (derived from testosterone, the male sex hormone) and estratetraenol (related to estrogen, the female sex hormone). A 2001 study from Sweden used magnetic resonance imaging (MRI) to look at the hypothalamus in the brain, which influences the release of sex hormones in the body. They found that only women’s hypothalamuses respond to androstadienone, and only men’s respond to estratetraenol. Exactly how and why are not known.

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